Skip to main content

New 'gene silencer' drug injections reduce cholesterol by 50% in clinical trial

The first in a new class of gene-silencing drugs, known as inclisiran, has halved cholesterol levels in patients at risk of cardiovascular disease. The findings come from the largest trial yet to test the safety and effectiveness of this kind of therapy. The technique, known as RNA interference (RNAi) therapy, essentially ‘switches off’ one of the genes responsible for elevated cholesterol.

Researchers from Imperial College London and their colleagues, who conducted the trial, say the twice-a-year treatment could be safely given with or without statins, depending on individual patient needs. Eventually, inclisiran could help to reduce the risk of heart attacks and stroke related to high cholesterol.

These initial results are hugely exciting for patients and clinicians,” said Professor Kausik Ray, lead author of the study from the Department of Primary Care and Public Health. “We appear to have found a versatile, easy-to-take, safe, treatment that provides sustained lowering of cholesterol levels and is therefore likely to reduce the risk of cardiovascular disease, heart attacks, and stroke. These reductions are over and above what can be already be achieved with statins alone or statins plus ezetemibe, another class of cholesterol-lowering drug”.

The study was published in the New England Journal of Medicine.

Comments

Popular posts from this blog

A View from the Community - Dr Dana Beale

As part of our View from the Community series of articles, our Year 6 Specialty Choice Lead Dr Ros Herbert interviewed community teacher Dr Dana Beale, to get the inside track on what it's like being a community teacher for Imperial College. To read more articles like this, please sign up to our newsletter by emailing b.broglia@imperial.ac.uk

Dana, tell me what first got you interested in homeless medicine? "Incredibly I was inspired by the same module I did as a student at Imperial College that I am now teaching on! Back then it was 'medical and social care of the homeless' and was based at the surgery for the homeless in Great Chapel Street - a fabulous service that showed me that primary care tailored to this vulnerable and challenging group existed and I promised myself there and then that I would return to work in this field."

What makes you so enthusiastic about this work? "I find this line of work a breath of fresh air; at times incredibly challenging …

Introducing the WATCCH Project - Widening Access to Careers in Community Healthcare

The Undergraduate Primary Care Education team in the Department of Primary Care and Public Health at Imperial College London has kicked off an exciting new work experience programme called WATCCH – Widening Access to Careers in Community Healthcare.
There is a shortage of work experience in the health sector for pupils, particularly for those who have no connection to healthcare professionals. WATCCH aims to open up work experience opportunities in the healthcare sector by offering placements for sixth form pupils from disadvantaged backgrounds to shadow various allied healthcare professionals in general practices. These 16/17 year olds have completed their GCSEs with good grades, do not have placements elsewhere, and are the first in their family applying to university. 
Pupils will attend a pre-placement induction at Imperial College's Charing Cross Hospital Campus, and will then have a 3-day work experience session at a general practice where they will observe a variety of allie…

What makes a good placement?

In the New Year, Dr Kevin Patel a GP ST3 on the Imperial VTS, takes a reflective look at the factors that go into making a good clinical attachment for trainees.
As GP trainees we are ‘encouraged’ to reflect; challenging encounters with patients, conversations with colleagues that could have gone better, moments when you felt like you were born to do this job. All of this is good fodder for your ePortfolio.
Not one to miss out on a reflective opportunity, I took a step back from a discussion that was taking place about difficult rotations, a conversation I imagine that is oft-repeated amongst GPs and hospital doctors up and down the country, and thought about how we could use our experience as GP trainees to feed into this.
As trainees we rotate into diverse placements, from paediatrics to public health to care of the elderly. I counted at least 15 distinct departments I have worked in since finishing medical school just over 5 years ago. This is more than any other specialty trainee…